Shanghai Institute of Pharmacy found functional genes of Staphylococcus epidermidis that are subject to oxidative stress

Staphylococcus epidermidis is an important pathogen causing nosocomial infections, and its tendency to cause sepsis and chronic prostatitis is increasing. Staphylococcus epidermidis enhances the resistance of bacteria to antibiotics and host defense systems due to the formation of biofilms, making clinical treatment very difficult. In the process of infection, Staphylococcus epidermidis must overcome the killing effect of reactive oxygen species (ROS) produced by the human immune system to successfully colonize and infect, and people know very well how Staphylococcus epidermidis feels and responds to oxidative stress signals. less.

Under the joint guidance of Researcher Yang Caiguang and Researcher Lan Lefu of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PhD student Liu Xing and others recently discovered a transcriptional regulator that senses oxidative stress in Staphylococcus epidermidis and named it AbfR. The study found that AbfR formed an intermolecular disulfide bond in the presence of oxidative stress signals, which changed the conformation of the protein dimer, and promoted the weakened DNA binding of the protein to the target promoter, thereby activating glutathione peroxidase The expression of genes and 2-keto acid dehydrogenase genes enhances the resistance of bacteria to oxidative stress killing, and leads to a reduction in the ability of bacteria to aggregate and form biofilms.

This study further clarified the molecular mechanism of S. epidermidis susceptible to oxidative stress signals, and provided a potential new role for small molecules to interfere with the formation of S. epidermidis biofilm. The research results were published online on December 27, 2012 Journal of Biological Chemistry.

This research work is another research progress made by the Institute of Interaction and Cooperation of New Types of Antimicrobial Research of the Institute of Medicine, and has received the support of Fudan University and Nanjing University. The research team recently reported the molecular mechanism of the important functional gene stp1 of Staphylococcus aureus (PNAS. 2012, 109: 15461-6) and the new target of potential drug action Gram-positive bacteria ClpP (J Biol Chem. 2011 , 286).

This work was supported by the National Natural Science Foundation of China, the "100 Persons Program" of the Chinese Academy of Sciences, and the support of the Shanghai Synchrotron Radiation Light Source.

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