Researchers from the China Astronaut Research and Training Center, the Hong Kong Baptist University School of Chinese Medicine, Jinan University and other institutions have recently made another breakthrough in the prevention and treatment of osteoporosis. The relevant research paper was published on December 9th. "Nature Medicine" (Nature Medicine) magazine.
Researcher Yingxian Li of the China Astronaut Research and Training Center and Professor Ge Zhang of the School of Chinese Medicine, Hong Kong Baptist University are co-corresponding authors of this paper.
Osteoporosis (osteoporosis) is a systemic bone disease characterized by a decrease in bone mass and destruction of the fine structure of the bone, which is manifested by increased brittleness of the bone, so the risk of fracture is greatly increased, even if it is a minor trauma or Fractures are easy to occur without trauma. Osteoporosis is a chronic disease caused by multiple factors. Before the fracture, there is usually no special clinical manifestation. There are more women than men in this disease, and they are more common in postmenopausal women and the elderly. With the increase of the elderly population in China, the incidence of osteoporosis is on the rise. Statistics released in 2008 show that 69.44 million people in China suffer from osteoporosis, and about 210 million people have low bone mass. The huge patient team and risk groups not only cause a serious economic burden on individuals, families, and governments, but also cause corresponding social problems.
MicroRNA (miRNA)) is a type of endogenous non-coding small-molecule single-stranded RNA with a length of about 19-24 nucleotides (nt). It is highly conserved during evolution and can pass through alkalis specific to the target gene mRNA Based on complementary complementation, it causes the degradation of target gene mRNA or inhibits its translation, and negatively regulates the expression of target genes, which plays an important regulatory role in various development and physiological processes of eukaryotes. In recent years, more and more research data indicate that miRNAs play an important role in regulating bone differentiation and bone formation.
In this new article, researchers confirmed in bone samples from elderly fracture patients that increased levels of miR-214 are associated with a lower degree of bone formation. Using miR-214 antagomir to specifically control the level of osteoblast miR-214 cells in miR-214 transgenic mice, ovariectomized mice, and hind limb mice, the researchers confirmed that miR-214 plays an inhibitory role in regulating bone formation. Further research showed that miR-214 directly targeting ATF4 inhibited osteoblast activity. In addition, the researchers also confirmed that the use of antagomir-214 and agomir-214 can increase or inhibit in vitro osteoblast activity and matrix mineralization.
These research data indicate that miR-214 plays a vital role in inhibiting bone formation. Inhibiting miR-214 in osteoblasts may be a potential anabolic strategy for improving osteoporosis.
About the Author:
Dr. Ge Zhang
Associate Professor of Teaching Department, School of Chinese Medicine, Hong Kong Baptist University, Expert in Basic Research and Clinical Translational Application of Orthopedics
From 2000 to 2003, he received research and clinical training under the joint training program of Shanghai University of Traditional Chinese Medicine and the Chinese University of Hong Kong orthopedics, and obtained a doctorate in clinical medicine in orthopedics in 2003. From 2004 to 2006, Dr. Ge Zhang began to engage in postdoctoral research in the Department of Orthopaedic Surgery and Traumatology of the Chinese University of Hong Kong. In 2012, Dr. Ge Zhang formally joined the Hong Kong Baptist University and participated in the establishment of the Institute of Translational Medicine for Osteoarthropathy of the Hong Kong Baptist University. Dr. Zhang Ge ’s research interests are mainly focused on the basic scientific research and clinical application of orthopedic diseases such as osteoporosis, osteonecrosis, fracture repair, osteoarthritis, rheumatoid arthritis, etc. , Journal of Bone & Mineral Research, Bone, Osteoporosis International and other orthopedic core journals published research results.
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