A medicine supply device for supplying medicine discharged from a medicine cassette containing a medicine, having a mouth (24) for discharging medicine discharged from the pill case, and being freely rotatably provided in the mouth (24). A shutter (37) for opening and closing the drug drop path (34) in the opening (24) and a roller (9) for opening and closing the drug drop path (34) in the opening (24) are rotatably opened and closed. The roller (9) is disposed at a position facing the height of the shutter (37) and rotates in conjunction with the opening and closing of the shutter (37). Such a medicine supply device can effectively eliminate the clogging of medicines in the mouth of a cartridge that discharges medicines into wrapping paper or the like.