Ankylosing spondylitis: the damage is not just low back pain!

One of the typical clinical manifestations of ankylosing spondylitis (AS) is inflammatory low back pain, which is characterized by insidious onset, nighttime pain, and reduction after activity. It is aggravated after rest, and anti-inflammatory analgesics are effective.

Nowadays, more and more patients, especially young patients, have gradually increased their understanding of AS. However, many patients still do not know enough about comprehensively. They only pay attention to the changes of low back pain during diagnosis and treatment.

In fact, the essence of AS is a systemic inflammatory disease. In the early stage of the disease, pain is a manifestation of inflammation. When the inflammation is controlled, most patients will reduce the pain to gradually disappear, but not necessarily. Some patients are treated, even if the pain disappears. However, the blood test still shows a clear inflammatory response. Once these patients are blinded by the illusion of self-perception, they will be taken lightly and have a negative impact on the next active treatment.

The persistence of inflammation is the root cause of continuous damage to the human body. Therefore, in addition to self-feeling, it is necessary to respect science. It is very important to regularly monitor the inflammation index in the hospital rheumatology department, which helps doctors adjust the treatment in time.

On the other hand, for patients with advanced disease, the inflammatory response is gradually quiescent, but the pain is still very obvious. The pain at this time is the manifestation of chronic bone and joint and tendon, nerve and other injuries, but the treatment is not effective. The therapeutic drugs should be converted accordingly. In order to achieve satisfactory results.

AS not only involves the spine, including the lumbar vertebrae, thoracic vertebrae and cervical vertebrae, but also gradually causes spinal rigidity, ligament callus, osteoporosis and even compression fractures. It can also affect joints such as the hips and shoulder joints; knee joints, ankle joints and toe joints. Such as the peripheral joints, as well as the pelvic, heel, patellar ligament and other tendon attachment points, causing joint effusion and soft tissue swelling, and gradually caused various erosion damage after timely treatment.

In addition, AS also causes damage to the internal organs and various organs of the human body, such as: aortic root dilatation, valvular dilatation, reflux, and even prolapse. The early stage of the disease is delayed due to the patient's absence of symptoms, and the chest has to undergo open heart valve replacement surgery. However, in the case of systemic inflammation is not completely controlled, after rushing blind surgery, the paravalvular leak is often difficult to avoid, the surgery ended in failure, and the surgery caused great physical and monetary losses to the patient.

Eye damage manifested as uveitis, vitreitis, retinitis, and even total ophthalmia. Patients with eye pain, redness, blurred vision, and even sudden blindness need to be treated as quickly as possible to avoid lifelong regret. Some patients with spinal arthritis may be associated with psoriasis (skin disease), inflammatory bowel disease (such as Crohn's disease, ulcerative colitis), and have long been misdiagnosed as common dermatitis or enteritis.

In addition, many patients with spondyloarthropathy have depression, anxiety, sleep disorders and other problems, young patients with sick workers are not uncommon, the feeling of being difficult to work pressure is always present, and even the salary is significantly affected.

The social life and recreational activities of many patients are significantly reduced. In the middle and late stage, the lumbar spine and cervical vertebrae are restricted in activity, the visual field is obviously reduced, and the quality of life such as toilet and exercise is very poor.

In order to avoid various damages in the middle and late stages of the disease, early diagnosis and rapid and complete control of inflammation can achieve the therapeutic goals of continuously improving symptoms, improving the level of body function, and finally restoring work ability and improving quality of life.

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