BBRC .: RNA interference interleukin advances new research in cancer treatment
Recently, researchers in the First Affiliated Hospital of Sun Yat-sen University used RuiboBio's siRNA (RiboBio) to silence the expression of interleukins, which revealed that the regulation of interleukins can improve the survival rate of breast cancer cells and significantly increase cancer cells. Sensitivity to docetaxel chemical drugs, enhance the efficacy of anti-cancer drugs. Related research was published in the journal Biochemical and Biophysical Research Communications.
Interleukin is a multifunctional chemokine that causes inflammation and is highly expressed in cancer patients such as estrogen receptor-negative breast cancer, which accelerates the progression of cancer. Researchers from the First Affiliated Hospital of Sun Yat-sen University have shown that IL-8 cell survival and the key regulatory role of cancer progression. The researchers silenced interleukin-8 (IL-8) using Reebok's synthetic high-specificity siRNA, and found that this process interfered with the proliferation of MDA-MB-231 and BT549 cells, and delayed the G1 and S phases of the cells. At the same time, the silencing of IL-8 gene leads to CDK up-regulation, inhibits p27, and down-regulates D1 cell cycle, reduces Akt phosphorylation, and inhibits NF-κB activity. Further research shows that silencing IL-8 can cause cell cycle arrest and increase the efficacy of docetaxel in treating breast cancer. This study has potential implications for the treatment of estrogen receptor-negative breast cancer.
Chemically synthesized siRNA is the simplest and fastest way to achieve gene silencing in cells or organisms, and it is also the best method for clinical treatment. Ruibo Bio has advanced RNA synthesis equipment and a full set of RNA synthesis patented technologies. It can design and synthesize highly specific siRNA products according to the needs of scientific research. At the same time, Ruibo Bio's experienced nucleic acid research and development team provides researchers with a full range of miRNA technology. Services, including miRNA mimic, miRNA inhibitor, miRNA agomir, miRNA antagomir, miRNA qRT-PCR, miRNA expression vector construction, miRNA target gene prediction analysis, miRNA expression profiling chip, miRNA next-generation high-throughput sequencing and other professional services Researchers carry out nucleic acid research quickly and efficiently.
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