According to the physicist organization network on December 4 (Beijing time), researchers at Rensselaer Polytechnic Institute have developed a new type of antibody. Each new type of antibody can bind up to 10 target proteins. Toxic proteins associated with Alzheimer's disease, Parkinson's disease, and type 2 diabetes have demonstrated unusual effectiveness in forming plaques.
The progressive development of the above diseases is caused by the plaques formed by protein accumulation that damage cells in the brain (Alzheimer's disease, Parkinson's disease) and pancreas (type 2 diabetes). Antibodies routinely used to combat these diseases have limitations, and cannot achieve the high concentrations required to completely inhibit the formation of toxic protein plaques.
To solve this problem, the research team led by Peter Tester, an assistant professor in the Department of Chemistry and Bioengineering at Rensselaer Polytechnic Institute, has developed a new method for making more potent antibodies. Each conventional antibody can usually only bind to 1 or 2 target proteins. In contrast, each new antibody can bind up to 10 target proteins. The enhanced efficiency makes the new antibody at a very low concentration. Can prevent the formation of toxic protein plaques. This is an important step towards the development of new treatments against diseases such as Alzheimer's disease and Parkinson's disease.
"It is extremely difficult for antibodies to enter the brain. Less than 5% of the antibodies injected into the patient's blood can enter the brain. Therefore, we need to make the antibody as strong as possible, so that even a small part of it can be completely blocked. Break the formation of toxic protein plaques associated with Alzheimer ’s disease and Parkinson ’s disease. Strategy, the resulting antibodies are more powerful than those produced by the immune system. "
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